Aire, Master of Many Trades

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Aire, Master of Many Trades

In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.

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ژورنال

عنوان ژورنال: Cell

سال: 2010

ISSN: 0092-8674

DOI: 10.1016/j.cell.2009.12.036